Selected Publications
- Musci RV, Andrie KM, Walsh MA, Valenti ZJ, Linden MA, Afzali MF, Bork S, Campbell M, Johnson T, Kail TE, Martinez R, Nguyen T, Sanford J, Wist S, Murrell MD, McCord JM, Hybertson BM, Zhang Q, Javors MA, Santangelo KS, Hamilton KL. Phytochemical compound PB125 attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a model of musculoskeletal decline. J Physiology. Published online 2022. doi:10.1113/jp282273
- Martinez W, Zhang Q, Linden MA, Schacher N, Darvish S, Mirek ET, Levy JL, Jonsson WO, Anthony TG, Hamilton KL. Rates of protein synthesis are maintained in brain but reduced in skeletal muscle during dietary sulfur amino acid restriction. Frontiers Aging. 2022;3:975129. doi:10.3389/fragi.2022.975129
- Walsh MA, Zhang Q, Musci RV, Hamilton KL. The combination of NRF1 and Nrf2 activators in myoblasts stimulate mechanisms of proteostasis without changes in mitochondrial respiration. Redox Muscle Physiology Exerc Sport. Published online 2022:100001. doi:10.1016/j.rimpes.2022.100001
- Wallace, M.A., N.W. Aguirre, G.R. Marcott1, A.G. Marshal1, L.M. Baehr1, D.C. Hughes, K.L. Hamilton, M.N. Roberts, J.A. Lopez-Dominguez, B. Miller, J.J. Ramsey and K. Baar. 2021. The ketogenic diet preserves skeletal muscle with aging. Aging Cell. 20(4): e13322. doi: 10.1111/acel.13322. Epub 2021 Mar 6. PMID: 33675103.
- Jonsson, W.O., N.S. Margolies, E.T. Mirek, Q. Zhang, M. Linden, C.M. Hill, C. Link, N. Bithi, B. Zalma, J.L. Levy, A.P. Pettit, J.W. Miller, C. Hine, C.D. Morrison, T.W. Gettys. B. Miller, K.L. Hamilton, R.C. Wek, and T.G. Anthony. 2020. Physiological responses to dietary sulfur amino acid restriction in mice are influenced by Atf4 status and biological sex. The Journal of Nutrition. Accepted.
- Musci, R.V., M.A. Walsh, A.R. Konopka, C.A. Wolff, F.F. Peelor III, R.F. Reiser II, B.F. Miller, K.S. Santangelo, K.L. Hamilton. 2020. The Dunkin Hartley Is a Model of Primary Osteoarthritis That Also Exhibits Early Onset Myofiber Remodeling That Resembles Human Musculoskeletal Aging. Frontiers in Physiology. 11: 571372. doi: 10.3389/fphys.2020.571372. PMID: 33192568.
- Wolff, C.A., M.M. Lawrence, H. Porter, Q. Zhang, J.J. Reid, J.L. Laurin, R.V. Musci, F.F. Peelor III, J.D. Wren, J.C. Price, R.A. Miller, K.L. Hamilton, and B.F. Miller. 2020. Sex differences in changes of protein synthesis with rapamycin treatment are minimized when metformin is added to rapamycin. Aging Cell. doi: 10.1007/s11357-020-00243-8. PMID: 32761290.
- West, AB Konopka AR, LeBreton KA, Miller BF, Hamilton KL, Leach HJ. 2020. Incorporating behavior change strategies into an exercise trial to improve physical activity maintenance among adults at high risk for type II diabetes. Journal of Aging and Physical Activity. Online ahead of print. PMID: 32470921.
- Reid, J.J. F.F. Peelor, M.A. Linden, R.A. Miller, K.L. Hamilton*, B.F. Miller. 2020. Brain protein synthesis rates in the UM-HET3 mouse following treatment with rapamycin or rapamycin with metformin. Journal of Gerontology: Biological Sciences. 75(1):40-49 PMID: 30864661.
- Wolff, C.A., J.J. Reid, R.V. Musci, Bruns, D.R., M.A. Linden, A.R. Konopka, F.F. Peelor, B.F. Miller, K.L. Hamilton. 2020. Differential effects of rapamycin and metformin in combination with rapamycin on mechanisms of proteostasis in cultured skeletal myotubes. Journal of Gerontology: Biological Sciences. 75(1):32-39. PMID: 30820523.
- Linden MA, Ross TT, Beebe DA, Gorgoglione MF, Hamilton KL, Miller BF, Braun B, Esler WP. Interaction between an SGLT2 inhibitor and exercise training. Metabolism. 2019 May 24. PMID: 31132381. DOI: 10.1016/j.metabol.2019.05.009
- Sieljacks P, Wang J, Groennebaek T, Rindom E, Jakobsgaard JE, Herskind J, Gravholt A, Møller AB, Musci RV, de Paoli FV, Hamilton KL, Miller BF, Vissing K. Six Weeks of Low-Load Blood Flow Restricted and High-Load Resistance Exercise Training Produce Similar Increases in Cumulative Myofibrillar Protein Synthesis and Ribosomal Biogenesis in Healthy Males. Frontiers in Physiology. 2019 May 29;10:649. PMID:31191347.
- Miller BF, Pharaoh GA, Hamilton KL, Peelor FF, Kirkland JL, Freeman WM, Mann SN, Kinter M, Price JC, Stout MB. Short-term calorie restriction and 17α-estradiol administration elicit divergent effects on proteostatic processes and protein content in metabolically active tissues. Journal of Gerontology A Biological Science Medical Science. 2019 May 10. PMID: 31074767.
- Musci RV, Linden MA, Hamilton KL. Exercise-induced mitohormesis for the maintenance of skeletal muscle and healthspan extension. Sports. Accepted 2019.
- Reid, J.J. F.F. Peelor, M.A. Linden, R.A. Miller, K.L. Hamilton*, B.F. Miller. Brain protein synthesis rates in the UM-HET3 mouse following treatment with rapamycin or rapamycin with metformin. Journal of Gerontology: Biological Sciences. 2019 Mar 13. pii: glz069. doi: 10.1093/gerona/glz069. [Epub ahead of print]. PMID: 30864661.
- Wolff, C.A., J.J. Reid, R.V. Musci, M.A. Linden, A.R. Konopka, F.F. Peelor, B.F. Miller, K.L. Hamilton*. Differential effects of rapamycin and metformin in combination with rapamycin on mechanisms of proteostasis in cultured skeletal myotubes. Journal of Gerontology: Biological Sciences. 2019 Mar 1. pii: glz058. doi: 10.1093/gerona/glz058. [Epub ahead of print]. PMID: 30820523.
- Groennebaek, T., N.R. Jespersen, J.E. Jakobsgaard, P. Sieljacks, J. Wang, E. Rindom, R.V. Musci, H.E. Bøtker, K.L. Hamilton*, B.F. Miller, F.V. de Paoli, and K. Vissing. 2018. Skeletal muscle mitochondrial protein synthesis and respiration increase with low-load blood flow restricted as well as high-load resistance training. Frontiers in Physiology. Dec 17;9:1796. doi: 10.3389/fphys.2018.01796. PMID: 30618808.
- Bruns, D.R., Ehrlicher, S.E., Biela, L.M., Peelor III, F.F., Miller, B.F., Hamilton, K.L. 2018. Activation of Nrf2 permits but vitamin C attenuates skeletal muscle adaptation to exercise. Journal of Applied Physiology. 125(2):661-671. PMID: 29856263.
- Munroe, M., Z.S. Mahmassani, S. Dvoretskiy, J.J. Reid, B.F. Miller, K.L. Hamilton, J.S. Rhodes, M.D. Boppart. 2018. Cognitive function is preserved in aged mice following long-term β-hydroxy β-methylbutyrate (HMB) supplementation. Nutritional Neuroscience. 19:1-13. PMID: 29914347.
- Miller, B.F., K.L. Hamilton, Z.R. Majeed, S.M. Abshire, A.L. Confides, A.M. Hayek, E.R. Hunt, P. Shipman, F.F. Peelor 3rd, T.A. Butterfield, E.E. Dupont-Versteegden. 2018. Enhanced skeletal muscle regrowth and remodelling in massaged and contralateral non-massaged hindlimb. The Journal of Physiology. 596(1):83-103. PMID: 29090454.
- Mitchell, C.M., R.F. D’Souza, S.M. Mitchell, V.C. Figueiredo, B.F. Miller, K.L. Hamilton, F.F. Peelor, M. Coronet, B. Durainayagam, A.C. Fanning, S.D. Poppitt , D. Cameron-Smith. 2017. The effects of protein supplementation during muscle disuse and recovery on muscle size and protein synthesis, a randomized controlled trial. Journal of Applied Physiology. doi: 10.1152/japplphysiol. 00803.2017. [Epub ahead of print]. PMID: 29122965.
- Miller, B.F., K.L. Hamilton, Z.R. Majeed, S.M. Abshire, A.L. Confides, A.J. Hayek, E.R. Hunt, P. Shipman, F.F. Peelor III, T.A. Butterfield, and E.E. Dupont-Versteegden. 2017. Enhanced skeletal muscle regrowth and remodelling in massaged and contralateral non-massaged hind limb. The Journal of Physiology. 596(1):83-103 PMID: 29090454.
- Miller, B. F. and Hamilton, K. L. (2017), Overview: the modulation of ageing through altered proteostasis. J Physiol, 595: 6381–6382. doi:10.1113/JP274997
- Musci RV, Hamilton KL, Miller BF., (2017), Targeting mitochondrial function and proteostasis to mitigate dynapenia. Eur J Appl Physiol.
- Konopka AR, Castor WM, Wolff CA, Musci RV, Reid JJ, Laurin JL, Valenti ZJ, Hamilton KL, Miller BF., (2017), Case Studies in Physiology: Skeletal Muscle Mitochondrial Protein Synthesis and Respiration in Response to the Energetic Stress of an Ultra-Endurance Race. J Appl Physiol
- Andrea Lee Estrada, William Max Hudson, Paul Y Kim, Claire Marie Stewart, Frederick F. Peelor, Yuren Wei, Dong Wang, Karyn L. Hamilton, Benjamin F. Miller, Michael J Pagliassotti (2017), Short-term changes in diet composition do not affect in vivo hepatic protein synthesis in rats. AJP: Endocrinology and Metabolism
- Hamilton, K. L. and Miller, B. F. (2017), Mitochondrial proteostasis as a shared characteristic of slowed aging: the importance of considering cell proliferation. J Physiol, 595: 6401–6407. doi:10.1113/JP274335
- Newsom, S. A., Miller, B. F., Hamilton, K. L., Ehrlicher, S. E., Stierwalt, H. D., & Robinson, M. M. (2017). Long-term rates of mitochondrial protein synthesis are increased in mouse skeletal muscle with high fat feeding regardless of insulin sensitizing treatment. AJP: Endocrinology and Metabolism, ajpendo.00144.2017.
- Hamilton, K. L., & Miller, B. F. (2017). Mitochondrial proteostasis as a shared characteristic of slowed aging: the importance of considering cell proliferation. The Journal of Physiology.
- Miller, B. F., Seals, D. R., & Hamilton, K. L. (2017). A viewpoint on considering physiological principles to study stress resistance and resilience with aging. Ageing Research Reviews, 38, 1–5.
- Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice. Pettit AP, Jonsson WO, Bargoud AR, Mirek ET, Peelor FF 3rd, Wang Y, Gettys TW, Kimball SR, Miller BF, Hamilton KL, Wek RC, Anthony TG. J Nutr. 2017 Jun;147(6):1031-1040. doi: 10.3945/jn.116.246710. Epub 2017 Apr 26. PMID: 28446632
- Ergogenic properties of metformin in simulated high altitude. Scalzo RL, Paris HL, Binns SE, Davis JL, Beals JW, Melby CL, Luckasen GJ, Hickey MS, Miller BF, Hamilton KL, Bell C. Clin Exp Pharmacol Physiol. 2017 Jul;44(7):729-738. doi: 10.1111/1440-1681.12761. PMID: 28394459
- Influence of Nrf2 activators on subcellular skeletal muscle protein and DNA synthesis rates after 6 weeks of milk protein feeding in older adults. Konopka AR, Laurin JL, Musci RV, Wolff CA, Reid JJ, Biela LM, Zhang Q, Peelor FF 3rd, Melby CL, Hamilton KL, Miller BF. Geroscience. 2017 Apr;39(2):175-186. doi: 10.1007/s11357-017-9968-8. Epub 2017 Mar 10. PMID: 28283797
- Mechanisms of in vivo ribosome maintenance change in response to nutrient signals. Molecular and Cellular Proteomics. Mathis, A.D., B.C.Naylor, R.H. Carson, E. Evans, J. Harwell, J. Knect, E. Hexem, F.F. Peelor, 3rd, B.F. Miller, K.L. Hamilton, M.K. Transtrum, B.T. Bikman, and J.C. Price. 2016. 2016 Dec 8. [Epub ahead of print]. PMID: 27932527.
- Physical activity and skeletal muscle aging. Miller BF, Hamilton KL. J Appl Physiol (1985). 2016 Sep 1:jap.00742.2016. doi: 10.1152/japplphysiol.00742.2016. [Epub ahead of print] No abstract available. PMID: 27586838
- Last Word on Viewpont: On the rigorous study of exercise adaptations: why mRNA might not be enough? Miller BF, Konopka AR, Hamilton KL. J Appl Physiol (1985). 2016 Aug 1;121(2):601. doi: 10.1152/japplphysiol.00505.2016. No abstract available. PMID: 27543662
- The rigorous study of exercise adaptations: why mRNA might not be enough. Miller BF, Konopka AR, Hamilton KL. J Appl Physiol (1985). 2016 Aug 1;121(2):594-6. doi: 10.1152/japplphysiol.00137.2016. Epub 2016 Mar 24. No abstract available. PMID: 27013604
- Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Martinez PA, McCord JM, Miller BF, Müller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE. Aging Cell. 2016 Jun 16. doi: 10.1111/acel.12496. [Epub ahead of print]
- What is the evidence for stress resistance and slowed aging? Hamilton KL, Miller BF. Exp Gerontol. 2016 Jun 4. pii: S0531-5565(16)30152-8. doi: 10.1016/j.exger.2016.06.001. [Epub ahead of print] Review. PMID: 27268049
- Circulating protein synthesis rates reveal skeletal muscle proteome dynamics. Shankaran M, King CL, Angel TE, Holmes WE, Li KW, Colangelo M, Price JC, Turner SM, Bell C, Hamilton KL, Miller BF, Hellerstein MK. J Clin Invest. 2016 Jan 4;126(1):288-302. doi: 10.1172/JCI79639. Epub 2015 Dec 14. PMID: 26657858
- Methazolamide Plus Aminophylline Abrogates Hypoxia-Mediated Endurance Exercise Impairment. Scalzo RL, Binns SE, Klochak AL, Giordano GR, Paris HL, Sevits KJ, Beals JW, Biela LM, Larson DG, Luckasen GJ, Irwin D, Schroeder T, Hamilton KL, Bell C. High Alt Med Biol. 2015 Dec;16(4):331-42. doi: 10.1089/ham.2015.0066. PMID: 26680684
- The Effects of Sympathetic Inhibition on Metabolic and Cardiopulmonary Responses to Exercise in Hypoxic Conditions. Scalzo RL, Peltonen GL, Binns SE, Klochak AL, Szallar SE, Wood LM, Larson DG, Luckasen GJ, Irwin D, Schroeder T, Hamilton KL, Bell C. Wilderness Environ Med. 2015 Dec;26(4):520-4. doi: 10.1016/j.wem.2015.04.004. Epub 2015 Jul 14. PMID: 26183071
- Hypoxia mediated pulmonary edema: potential influence of oxidative stress, sympathetic activation and cerebral blood flow. Khademi S, Frye MA, Jeckel KM, Schroeder T, Monnet E, Irwin DC, Cole PA, Bell C, Miller BF, Hamilton KL. BMC Physiol. 2015 Oct 9;15:4. doi: 10.1186/s12899-015-0018-4. PMID: 26449218
- Long-lived Snell dwarf mice display increased proteostatic mechanisms that are not dependent on decreased mTORC1 activity. Drake JC, Bruns DR, Peelor FF, Biela LM, Miller RA, Miller BF, Hamilton KL. Aging Cell. 2015 Jun;14(3):474-82. doi: 10.1111/acel.12329. Epub 2015 Feb 26 PMID: 25720574.
- Assessment of protein synthesis in highly aerobic canine species at the onset and during exercise training. Miller BF, Ehrlicher SE, Drake JC, Peelor FF 3rd, Biela LM, Pratt-Phillips S, Davis M, Hamilton KL. J Appl Physiol (1985). 2015 Jan 22:jap.00982.2014. doi: 10.1152/japplphysiol.00982.2014. [Epub ahead of print] PMID:25614602 [PubMed – as supplied by publisher]
- Modeling the contribution of individual proteins to mixed skeletal muscle protein synthetic rates over increasing periods of label incorporation. Miller BF, Wolff CA, Peelor FF 3rd, Shipman PD, Hamilton KL. J Appl Physiol (1985). 2015 Jan 15:jap.00987.2014. doi: 10.1152/japplphysiol.00987.2014. [Epub ahead of print] PMID: 25593288 [PubMed – as supplied by publisher]
- The measurement of protein synthesis for assessing proteostatsis in studies of slowed aging. Miller BF, Drake JC, Naylor B, Price JC, Hamilton KL. Ageing Res Rev. 2014 Oct 2. pii: S1586-1637(14)00108-1. doi: 10.1016/j.arr.2014.09.005. [Epub ahead of print] PMID:25283966 [PubMed – as supplied by publisher]
- Evaluation of quantitative performance of sequential immobilized metal affinity chromatographic enrichment for phosphopeptides. Sun Z, Hamilton KL, Reardon KF.Anal Biochem. 2014 Jan 15;445:30-7. doi: 10.1016/j.ab.2013.09.025. Epub 2013 Oct 1.PMID: 24096195 [PubMed – indexed for MEDLINE]
- Long-lived crowded litter mice have an age-dependent increase in protein synthesis to DNA synthesis ratio and mTORC1-substrate phosphorylation. Sun Z, Hamilton KL, Reardon KF.Anal Biochem. 2014 Jan 15;445:30-7. doi: 10.1016/j.ab.2013.09.025. Epub 2013 Oct 1.PMID: 24096195 [PubMed – indexed for MEDLINE]
- Participation in a 1000-mile race increases the oxidation of carbohydrate in Alaskan sled dogs. Miller BF, Drake JC, Peelor FF 3rd, Biela LM, Geor RJ, Hinchcliff KW, Davis M, Hamilton KL. J Appl Physiol . 2014 Aug 21. pii: jap.00588.2014. [Epub ahead of print] PMID: 25150223 [PubMed – as supplied by publisher]
- Greater muscle protein synthesis and mitochondrial biogenesis in males compared with females during sprint interval training. Scalzo RL, Peltonen GL, Binns SE, Shankaran M, Giordano GR, Hartley DA, Klochak AL, Lonac MC, Paris HL, Szallar SE, Wood LM, Peelor FF 3rd, Holmes WE, Hellerstein MK, Bell C, Hamilton KL, Miller BF. FASEB J. 2014 Jun;28(6):2705-14. doi: 10.1096/fj.13-246595. Epub 2014 Mar 5. PMID: 24599968 [PubMed – in process]
- Assessment of Mitochondrial Biogenesis and mTORC1 Signaling During Chronic Rapamycin Feeding in Male and Female Mice. Drake JC, Peelor FF 3rd, Biela LM, Watkins MK, Miller RA, Hamilton KL, Miller BF. J Gerontol A Biol Sci Med Sci. 2013 May 8. [Epub ahead of print] PMID: 23657975 [PubMed – as supplied by publisher]
- Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress. Reuland DJ, Khademi S, Castle CJ, Irwin DC, McCord JM, Miller BF, Hamilton KL. Free Radic Biol Med. 2012 Nov 30;56C:102-111. doi: 10.1016/j.freeradbiomed.2012.11.016. [Epub ahead of print] PMID:23201694 [PubMed – in process]
- Calorie Restriction Does Not Increase Short-term or Long-term Protein Synthesis. Miller BF, Robinson MM, Reuland DJ, Drake JC, Peelor FF 3rd, Bruss MD, Hellerstein MK,Hamilton KL. J Gerontol A Biol Sci Med Sci. 2012 Oct 26. [Epub ahead of print] PMID:23105041 [PubMed – indexed for MEDLINE]
- Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge. Donovan EL, McCord JM, Reuland DJ, Miller BF, Hamilton KL. Oxid Med Cell Longev. 2012;2012:132931. doi: 10.1155/2012/132931. Epub 2012 May 22. PMID:22685617 [PubMed – indexed for MEDLINE]
- A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction. Miller BF, Robinson MM, Bruss MD, Hellerstein M, Hamilton KL. Aging Cell. 2012 Feb;11(1):150-61. PMID:22081942 [PubMed – indexed for MEDLINE]
- Phosphoproteomics and molecular cardiology: techniques, applications and challenges. Sun Z, Hamilton KL, Reardon KF. J Mol Cell Cardiol. 2012 Sep;53(3):354-68. doi: 10.1016/j.yjmcc.2012.06.001. Epub 2012 Jun 9. Review. PMID: 22691689 [PubMed – indexed for MEDLINE]
- Concentration-dependent effects of the soy phytoestrogen genistein on the proteome of cultured cardiomyocytes. Sun Z, Biela LM, Hamilton KL, Reardon KF.J Proteomics. 2012 Jun 27;75(12):3592-604. doi: 10.1016/j.jprot.2012.04.001. Epub 2012 Apr 11.PMID: 22521270 [PubMed – indexed for MEDLINE]
- Dr. Karyn L. Hamilton – PubMed