Our laboratory focuses on identifying the mechanisms by which nutrient excess and obesity cause dysfunction of the cardiovascular system.
In particular, through a close collaboration with Dr. Tiffany Weir in FSHN, we are currently utilizing isolated cell systems, experimental animals, and human subjects to examine the role of the gut microbiome on the development and progression of cardiometabolic diseases such as heart disease and diabetes.
Dr. Christopher Gentile, Director
Suppression of gut dysbiosis reverses Western diet-induced vascular dysfunction.
Gut microbiota regulates cardiac ischemic tolerance and aortic stiffness in obesity
The gut microbiota at the intersection of diet and human health
Transplantation of an obesity-associated human gut microbiota to mice induces vascular dysfunction and glucose intolerance