Our Research
Research within the Sensorimotor Neuroimaging Laboratory is designed to understand the contributions of the brain’s structural and functional networks to everyday movements and to leverage this understanding to develop new therapeutic interventions for individuals with sensorimotor dysfunction. Through the use of novel motor training interventions, paired with neuroimaging, we are developing methods that predict intervention responsiveness and promote neural plasticity. We utilize a range of neuroimaging techniques including functional and structural magnetic resonance imaging, diffusion tensor imaging, and transcranial magnetic stimulation to assess neuroanatomy and neurophysiologic function. These state of the art imaging techniques are integrated with experimental paradigms relying on the biomechanical analysis of sensorimotor control to provide a comprehensive view of the neural control of movement.
Current Projects
Splitting the difference: Split-belt Treadmill Training To Improve Gait Symmetry in PwMS
The majority of people with MS (PwMS) experience significant gait asymmetries, or differences between the left and right legs during walking, leading to an increased risk of falls and musculoskeletal injury. Split-belt treadmill training, where one leg is moving faster than the other leg, alters each leg’s stepping pattern. Through our research we have demonstrated that this training can improve gait symmetry in PwMS. However, previous research has shown that sensory dysfunction alters the effectiveness of split-belt treadmill training. We are currently using lower limb sensory nerve stimulation to improve the adaptation and retention of this training in PwMS. Additionally, there is limited research investigating how the brain alters its signaling to the body during split-belt treadmill training. In this ongoing study, PwMS and controls are completing split-belt treadmill training with sensory nerve stimulation on their legs, and with live brain activity being measured using a specialized brain imaging cap. A more comprehensive understanding of the how the brain controls gait adaptation in PwMS may contribute to the development of effective and targeted walking rehabilitation in PwMS.
Overlooked No More: Uncovering the Impact of the Menstrual Cycle on Brain and Muscle Function in Women
From puberty to menopause, women spend nearly half of their lifetime experiencing a menstrual cycle or using hormonal contraception to suppress the menstrual cycle. The menstrual cycle is known for its role in regulating female reproduction, but it may also impact other body functions like movement. Many neurotypical women report that their capacity to exercise is impacted by the menstrual cycle. Many women with multiple sclerosis report that their symptoms of fatigue and muscle weakness change across the menstrual cycle. However, little is known about the magnitude (how much) and the mechanisms (the process) by which the menstrual cycle may be impacting movement in neurotypical women or in women with multiple sclerosis.
Our on-going work will bring attention to this overlooked aspect of women’s health by determining the impact of the menstrual cycle on brain function and muscle fatigue. This project will use a novel tool to stimulate the brain, transcranial magnetic stimulation (TMS), to uncover the impact of the menstrual cycle on brain communication. It will also determine the impact of different menstrual cycle phases on muscle fatigue, walking performance, and balance.